Perisyl Combi (Perindopril Erbumine And Indapamide Hemihydrate)
Complete patient guide for uses, dosage, side effects, and safety information
Prescription RequiredQuick Facts
What Is Perisyl Combi Used For?
Perisyl Combi is a combination medication that contains two active ingredients: perindopril erbumine (an ACE inhibitor) and indapamide hemihydrate (a diuretic or ‘water tablet’). It is specifically prescribed to treat high blood pressure.
Primary Uses
Perisyl Combi is used to treat high blood pressure (hypertension). High blood pressure occurs when your blood pressure stays higher than needed, even when you are calm and relaxed. If left untreated, it can lead to serious health problems including stroke, heart disease, and kidney failure.
How It Works
Perindopril belongs to a group of medicines called angiotensin converting enzyme (ACE) inhibitors, while indapamide belongs to a group of medicines called diuretics. Together, they help lower your blood pressure by different mechanisms.
Good to know: There is no evidence that Perisyl Combi is addictive.
How to Take Perisyl Combi
Your doctor will select the appropriate dose when prescribing Perisyl Combi for you. It’s important to follow their instructions carefully and take the medication regularly.
Dosage Instructions
The usual dose is one tablet once daily. Swallow your tablet with water, preferably in the morning. Perisyl Combi treatment is usually for life, so you should keep taking the tablets regularly unless advised otherwise by your doctor.
What If You Miss a Dose?
If your next usual dose is less than 6 hours away, just leave out the dose that you missed and take the next dose at the usual time. If your next dose is more than 6 hours away, take the missed dose as soon as you realize, then take the next dose at the usual time and continue as normal.
Important: Do not take a double dose to make up for the dose you missed.
Side Effects
Like all medications, this medicine can cause side effects. Most are mild and temporary, but some require medical attention.
Common Side Effects
These side effects occur relatively frequently and usually don’t require emergency care:
- Nausea, vomiting, diarrhea, constipation
- Dry mouth
- Cough (often dry and irritating)
- Low blood pressure
- Muscle spasms, tenderness, or weakness
- Headache, dizziness, vertigo
- Pins and needles sensation
- Mood changes, sleep disorders
- Skin rash
- Nosebleeds
- Generally feeling unwell
Seek immediate medical attention if you experience:
- Concentrated urine (dark colored)
- Chest pain, palpitations
- Bleeding or bruising more easily than normal
- Frequent infections
- Depression, anxiety, confusion
- Decrease in vision or eye pain
- Severe dizziness or fainting
- Difficulty breathing or wheezing
- Tightening of the chest
- Severe allergic reaction
- Swelling of extremities
- Large blisters on skin
Important Warnings
There are several important conditions and situations where Perisyl Combi should not be used or requires special caution. Always inform your doctor about your complete medical history.
Who Should Not Take Perisyl Combi
Do not take if you are allergic to perindopril, indapamide, sulfonamide antibiotics, thiazide diuretics, or other ACE inhibitors. Also avoid if you have kidney problems with reduced blood supply, severe liver disease, low blood potassium, are undergoing certain blood treatments, taking aliskiren with diabetes/kidney problems, or have experienced serious swelling (angioedema) in the past.
Medical Conditions to Discuss
Tell your doctor if you have kidney or liver disease, diabetes, gout, heart disease, high or low potassium levels, are on dialysis, have lupus or scleroderma, are undergoing surgery or medical tests with contrast agents, or are taking lithium or other blood pressure medications.
Pregnancy and Breastfeeding
Do not take Perisyl Combi if you are pregnant, trying to become pregnant, or breastfeeding. Tell your doctor immediately if you become pregnant while taking this medicine, as it may cause serious harm to your unborn baby.
Special Populations: People of African origin may have a higher risk of angioedema and this medicine may be less effective. Elderly people can generally use Perisyl Combi safely but may need additional monitoring if they have reduced kidney function.
Drug Interactions
Many medications can interact with Perisyl Combi and affect how it works. Always tell your doctor about all medicines, vitamins, and supplements you are taking.
- Steroid medicines
- Other diuretics (amiloride, spironolactone, triamterene)
- Heart rhythm medications (quinidine, amiodarone, sotalol)
- Other blood pressure medications (ACE inhibitors, ARBs, aliskiren)
- Antibiotics (trimethoprim, moxifloxacin)
- Anti-inflammatory drugs (high-dose aspirin, ibuprofen)
- Mental health medications (lithium, antidepressants, antipsychotics)
- Diabetes medications (metformin, insulin, gliptins)
- Potassium supplements and salt substitutes
- Cancer medications (vandetanib, oxaliplatin)
- Immunosuppressants (ciclosporin, tacrolimus)
- Gold salts for rheumatoid arthritis
Alcohol & Driving
Perisyl Combi can affect your ability to drive or operate machinery, especially when you first start taking it or if you experience dizziness or weakness.
Driving and Operating Machinery
Be careful before you drive or use any machines or tools until you know how Perisyl Combi affects you. You may feel light-headed or dizzy when you begin treatment because your blood pressure is falling. Getting up more slowly from sitting or lying positions can help your body adjust.
Storage
Store Perisyl Combi below 25°C in a cool, dry place away from moisture, heat, and sunlight. Keep tablets in their original pack until it’s time to take them. Store in a location where children cannot reach, preferably in a locked cupboard at least 1.5 meters above ground level.
Overdose Information
If you think you or anyone else has taken too much Perisyl Combi, seek urgent medical attention immediately. Contact the Poisons Information Centre (Australia: 13 11 26), your doctor, or go to the nearest hospital emergency department. The most likely effect of overdose is dangerously low blood pressure, which can cause dizziness. Other symptoms may include nausea, vomiting, cramps, sleepiness, confusion, and changes in urine production.
Frequently Asked Questions
The medication begins working to lower blood pressure, but the source doesn’t specify exact timing. Your doctor will monitor your response to determine effectiveness.
The medication should be taken with water, preferably in the morning. The source doesn’t specify whether it should be taken with or without food.
No, there is no evidence that Perisyl Combi is addictive.
Do not stop taking Perisyl Combi or change the dosage without checking with your doctor. Treatment is usually for life to help control blood pressure.
Yes, elderly people can generally use Perisyl Combi safely. However, some older people have reduced kidney function, in which case additional care may be required.
If your next dose is less than 6 hours away, skip the missed dose. If more than 6 hours away, take the missed dose as soon as you remember, then continue with your regular schedule. Never take a double dose.
Make sure you drink enough water during exercise and hot weather, especially if you sweat a lot. This will help you avoid dizziness or light-headedness caused by a sudden drop in blood pressure.
Important Disclaimer
This information is intended for general educational purposes only and should not be considered medical advice. Always consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
If you think you may have a medical emergency, call your doctor or emergency services immediately.