Kozenis (Tafenoquine)
Complete patient guide for uses, dosage, side effects, and safety information
Quick Facts
What Is Kozenis Used For?
Kozenis is an antimalarial medication that contains tafenoquine. It is specifically used to eliminate certain forms of malaria, particularly Plasmodium vivax, and to help prevent its recurrence. It is typically administered alongside chloroquine, which treats the acute stage of malaria.
Primary Uses
Kozenis is used to treat and prevent malaria caused by Plasmodium vivax.
How It Works
Tafenoquine works by targeting the malaria parasite in the liver to eliminate dormant forms and prevent future infections.
Good to know: Kozenis is not considered addictive.
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How to Take Kozenis
Kozenis should be taken with food to ensure proper absorption. It is usually given on the first or second day of a chloroquine treatment course.
Dosage Instructions
Adults and children over 35 kg should take two 150 mg tablets as a single 300 mg dose. For children aged 2 years and older weighing between 10 kg and 35 kg, the doctor will determine the appropriate dosage based on the child's weight.
What If You Miss a Dose?
If you miss a dose, take it as soon as you remember. If it's almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Important: Never double the dose of Kozenis.
Available Tablet Strengths
Side Effects
Like all medications, this medicine can cause side effects. Most are mild and temporary, but some require medical attention.
Common Side Effects
These side effects occur relatively frequently and usually don’t require emergency care:
- difficulty sleeping
- headache
- dizziness
- nausea
- vomiting
Seek immediate medical attention if you experience:
- haemolytic anaemia (darkening of urine, dizziness, confusion, tiredness, shortness of breath)
- methaemoglobinaemia (bluish skin, darkening of urine, dizziness, confusion, tiredness)
- severe allergic reactions (hives, swelling of face or mouth, difficulty breathing)
Important Warnings
There are important safety considerations when using Kozenis.
Who Should Not Take Kozenis
Do not take Kozenis if you have G6PD deficiency, are unsure of your G6PD status, are pregnant, or are breastfeeding a child with G6PD deficiency.
Medical Conditions to Discuss
Discuss any history of psychiatric disorders, allergies to medications, or conditions that may increase the risk of side effects with your doctor.
Pregnancy and Breastfeeding
Do not take Kozenis if you are pregnant or plan to become pregnant. Avoid pregnancy for at least 3 months after taking Kozenis. If you are breastfeeding, consult your doctor, especially if your child has G6PD deficiency.
Drug Interactions
Some medications can interact with Kozenis, affecting its efficacy.
- metformin
Alcohol & Driving
Kozenis is unlikely to impair your ability to drive or operate machinery.
Alcohol
There are no specific warnings about alcohol consumption while taking Kozenis.
Driving and Operating Machinery
Kozenis should not affect your ability to drive or use machinery.
Storage
Store Kozenis in its original packaging in a cool, dry place away from moisture, heat, and sunlight. Keep it out of reach of children.
Overdose Information
If you suspect an overdose of Kozenis, seek immediate medical attention. Contact the Poisons Information Centre at 13 11 26 or go to the nearest hospital.
Frequently Asked Questions
Kozenis starts to work by targeting the malaria parasite in the liver, but the exact time for noticeable effects can vary.
Yes, Kozenis should be taken with a meal to ensure proper absorption.
No, Kozenis is not considered addictive.
Do not stop taking Kozenis without consulting your doctor, as it may affect your treatment.
There are no specific warnings against alcohol consumption while taking Kozenis.
Weight gain is not listed as a side effect of Kozenis.
Consult your doctor for advice on the safety of Kozenis in elderly patients, especially those with pre-existing conditions.
If you miss a dose, take it as soon as you remember, but skip it if it's almost time for your next dose.
Important Disclaimer
This information is intended for general educational purposes only and should not be considered medical advice. Always consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
If you think you may have a medical emergency, call your doctor or emergency services immediately.