Ibrance tablets (Palbociclib)
Complete patient guide for uses, dosage, side effects, and safety information
Quick Facts
What Is Ibrance tablets Used For?
Ibrance contains palbociclib and is prescribed for patients with advanced breast cancer that is hormone receptor-positive and HER2-negative. It is typically used in combination with other hormonal therapies.
Primary Uses
Ibrance is primarily used to treat advanced breast cancer.
How It Works
Ibrance works by inhibiting certain proteins (cyclin-dependent kinases) that are involved in cancer cell growth.
Good to know: Ibrance is not addictive.
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How to Take Ibrance tablets
Ibrance is taken orally as a tablet. It is important to follow your doctor's instructions regarding dosage.
Dosage Instructions
The usual dose for adults with advanced breast cancer is one 125 mg tablet taken daily for 21 days, followed by a 7-day break. This cycle is repeated as directed by your doctor.
What If You Miss a Dose?
If you miss a dose, take it at your regular time. Do not take a double dose to make up for a missed one.
Important: Never double dose to compensate for a missed dose.
Available Tablet Strengths
Side Effects
Like all medications, this medicine can cause side effects. Most are mild and temporary, but some require medical attention.
Common Side Effects
These side effects occur relatively frequently and usually don’t require emergency care:
- nausea
- diarrhea
- vomiting
- fatigue
- loss of appetite
- hair thinning
- skin rash
- bruising or bleeding easily
Seek immediate medical attention if you experience:
- allergic reactions (e.g., difficulty breathing, swelling)
- signs of infection (e.g., fever, chills)
- persistent bruising or bleeding
- severe respiratory issues
Important Warnings
There are several important warnings associated with Ibrance that patients should be aware of.
Who Should Not Take Ibrance tablets
Do not take Ibrance if you are allergic to palbociclib or any of its ingredients.
Medical Conditions to Discuss
Discuss any history of blood disorders, infections, lung issues, kidney or liver problems with your doctor.
Pregnancy and Breastfeeding
Ibrance may harm a developing baby and should not be used during pregnancy. Effective contraception is advised during treatment and for a month after the last dose. Breastfeeding is not recommended while taking Ibrance.
Drug Interactions
Ibrance can interact with several other medications, so it's crucial to inform your doctor about all medicines you are taking.
Grapefruit interaction: Avoid grapefruit and grapefruit juice while taking Ibrance, as they may affect how the drug works.
- medicines for fungal infections (e.g., posaconazole, voriconazole)
- antibiotics (e.g., erythromycin, clarithromycin)
- HIV medications (e.g., atazanavir, ritonavir)
- hepatitis C treatments (e.g., elbasvir/grazoprevir)
- tuberculosis medications (e.g., rifampin)
- pain medications (e.g., alfentanil, fentanyl)
- medications for organ rejection (e.g., cyclosporine)
- migraine treatments (e.g., dihydroergotamine)
- cancer treatments (e.g., everolimus)
- epilepsy medications (e.g., phenytoin, carbamazepine)
- St John's wort
- nefazodone
- modafinil
Alcohol & Driving
Be cautious with alcohol consumption and operating vehicles while on Ibrance, as the effects on your ability to drive are not fully known.
Alcohol
Consult your doctor about alcohol use while taking Ibrance.
Driving and Operating Machinery
Use caution when driving or using machinery until you know how Ibrance affects you.
Storage
Store Ibrance in a cool, dry place below 30°C, and keep it in its original packaging to protect it from light.
Overdose Information
If you suspect an overdose, seek immediate medical attention. Contact your doctor or the Poisons Information Centre at 13 11 26.
Frequently Asked Questions
The time it takes for Ibrance to show effects can vary; consult your doctor for specific expectations.
Ibrance can be taken with or without food, but follow your doctor's instructions.
No, Ibrance is not considered addictive.
Do not stop taking Ibrance without consulting your doctor, as it may affect your treatment.
Consult your doctor regarding alcohol consumption while on Ibrance.
Weight gain is not specifically mentioned as a side effect; discuss any concerns with your doctor.
Elderly patients should discuss their overall health and any other medications with their doctor before taking Ibrance.
Important Disclaimer
This information is intended for general educational purposes only and should not be considered medical advice. Always consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
If you think you may have a medical emergency, call your doctor or emergency services immediately.