Augtyro (Repotrectinib)
Complete patient guide for uses, dosage, side effects, and safety information
Quick Facts
What Is Augtyro Used For?
Augtyro is a medication that contains repotrectinib, specifically designed for adults diagnosed with a type of lung cancer known as non-small cell lung cancer (NSCLC) that is linked to changes in the ROS1 gene.
Primary Uses
It is primarily used to treat advanced NSCLC that has spread to other parts of the body and has shown a change in the ROS1 gene.
How It Works
Augtyro works by blocking abnormal ROS1 proteins that contribute to the uncontrolled growth of cancer cells, potentially slowing or stopping their growth.
Good to know: Augtyro is not considered addictive.
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How to Take Augtyro
It is important to follow your doctor's instructions on how to take Augtyro correctly.
Dosage Instructions
The recommended starting dose is 160 mg once daily for the first 14 days, followed by 160 mg twice daily. Your doctor may adjust this based on your response to treatment.
What If You Miss a Dose?
If you miss a dose or vomit after taking it, take the next dose as prescribed. Do not double up on doses.
Important: Never take a double dose to make up for a missed one.
Available Tablet Strengths
Side Effects
Like all medications, this medicine can cause side effects. Most are mild and temporary, but some require medical attention.
Common Side Effects
These side effects occur relatively frequently and usually don’t require emergency care:
- taste changes
- numbness and tingling
- constipation
- fatigue
- nausea
- muscle weakness
- headaches
- sleep disorders
- weight gain
- joint pain
- vomiting
- diarrhea
- muscle pain
- leg and/or arm pain
Seek immediate medical attention if you experience:
- dizziness and confusion
- lung problems (dry cough, wheezing, shortness of breath)
- liver issues (yellowing skin/eyes, dark urine, loss of appetite)
- muscle pain or weakness
- high uric acid levels (swollen joints, decreased urine output)
- bone fractures
Impulse Control Issues
There is no specific mention of impulse control issues related to Augtyro.
Important Warnings
There are several important warnings to consider before using Augtyro.
Who Should Not Take Augtyro
Do not use Augtyro if you are allergic to repotrectinib or any of its ingredients. It is also not recommended for pregnant individuals.
Medical Conditions to Discuss
Discuss any history of lung problems, dizziness, memory loss, or coordination issues with your doctor.
Pregnancy and Breastfeeding
Avoid becoming pregnant while taking Augtyro, as it may harm the baby. Do not breastfeed during treatment.
Elderly Patients With Dementia: Elderly patients, especially those with dementia, should use caution when taking Augtyro due to potential cognitive side effects.
Drug Interactions
Certain medications and foods may interact with Augtyro, affecting its efficacy.
Grapefruit interaction: Avoid grapefruit and grapefruit juice while taking Augtyro, as they can increase the medication's levels in the blood to potentially harmful levels.
- Ritonavir
- Saquinavir
- Ketoconazole
- Itraconazole
- Voriconazole
- Posaconazole
- Carbamazepine
- Phenytoin
- Rifampicin
- St. John's Wort
- Apalutamide
- Sirolimus
- Tacrolimus
- Cyclosporine
- Alfentanil
- Bupropion
Alcohol & Driving
Be cautious with alcohol consumption and operating vehicles while on Augtyro.
Alcohol
Avoid alcohol as it may exacerbate side effects like dizziness.
Driving and Operating Machinery
If you experience dizziness or confusion, do not drive or operate heavy machinery.
Temperature Regulation
There are no specific warnings regarding temperature regulation.
Storage
Store Augtyro in a cool, dry place away from moisture and heat. Keep it out of reach of children and do not use after the expiration date.
Overdose Information
If you suspect an overdose, seek immediate medical attention. Contact your doctor or go to the nearest hospital, bringing the medication packaging with you.
Frequently Asked Questions
The time it takes for Augtyro to show effects can vary, and your doctor will monitor your progress.
You can take Augtyro with or without food, but swallow the capsules whole.
No, Augtyro is not considered addictive.
Do not stop taking Augtyro without consulting your doctor, as it is important to continue treatment as prescribed.
It is advisable to avoid alcohol while taking Augtyro due to potential side effects.
Weight gain is listed as a common side effect, so monitor your weight during treatment.
Elderly patients should use caution when taking Augtyro, especially those with dementia.
If you miss a dose, take the next one as prescribed, but do not double up.
Important Disclaimer
This information is intended for general educational purposes only and should not be considered medical advice. Always consult your healthcare provider or pharmacist before starting, stopping, or changing any medication.
If you think you may have a medical emergency, call your doctor or emergency services immediately.