Pentasa Suppositories (Mesalazine)

Complete patient guide for uses, dosage, side effects, and safety information

Prescription Required

Quick Facts

Generic Name

mesalazine

Drug Class

anti-inflammatory agent

Used For

treating proctitis, an inflammation of the rectum

How Taken

insert one suppository (1 g) into the rectum at bedtime

What Is Pentasa Suppositories Used For?

Pentasa Suppositories contain mesalazine, which helps reduce inflammation in the rectum. It is primarily used to treat proctitis, a condition characterized by inflammation, ulcers, and sores in the rectum that can lead to bleeding, stomach pain, and diarrhea.

Primary Uses

Pentasa is used to treat proctitis.

How It Works

Mesalazine works by reducing inflammation in the rectum.

Good to know: Pentasa is not addictive.

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How to Take Pentasa Suppositories

Follow your doctor's instructions for using Pentasa Suppositories to ensure effective treatment.

Dosage Instructions

The recommended dosage is one suppository (1 g) inserted into the rectum once daily at bedtime.

What If You Miss a Dose?

If you forget to use a suppository, skip the missed dose and continue with your next dose at the scheduled time. Do not double the dose.

Important: Never double dose to make up for a missed dose.

Side Effects

Like all medications, this medicine can cause side effects. Most are mild and temporary, but some require medical attention.

Common Side Effects

These side effects occur relatively frequently and usually don’t require emergency care:

headache
diarrhea
abdominal or stomach pain
nausea
vomiting
flatulence
mild skin rash
discomfort or itching in the anus or rectum

Seek immediate medical attention if you experience:

chest pain
irregular heartbeat
shortness of breath
inflammation of the pancreas
unusual bleeding
numbness or tingling in arms and legs
worsening of condition
liver disease
kidney disease
allergic reactions

Important Warnings

It's crucial to be aware of certain warnings before using Pentasa.

Who Should Not Take Pentasa Suppositories

Do not use Pentasa if you are allergic to mesalazine or any of its ingredients, or if you have severe kidney or liver problems.

Medical Conditions to Discuss

Inform your doctor if you have any known allergies, kidney or liver issues, a bleeding disorder, or a history of asthma.

Pregnancy and Breastfeeding

Consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding, as Pentasa should be used with caution during these times.

Drug Interactions

Be cautious when using Pentasa with other medications.

Anticoagulants (e.g., warfarin)
Sulphonylureas (e.g., glibenclamide, glipizide)
Methotrexate
Glucocorticoids (e.g., prednisolone)
Probenecid or sulfinpyrazone
Spironolactone or frusemide
Rifampicin
Azathioprine
Mercaptopurine
Thioguanine

Alcohol & Driving

Pentasa is not expected to impair your ability to drive or operate machinery.

Alcohol

Consult your doctor regarding alcohol consumption while using Pentasa.

Driving and Operating Machinery

Pentasa is not expected to affect your ability to drive.

Storage

Store Pentasa Suppositories in a cool, dry place below 25°C, away from moisture and heat. Keep out of reach of children.

Overdose Information

If you suspect an overdose or if the suppository has been swallowed, seek immediate medical attention. Contact the Poisons Information Centre at 13 11 26 or go to the nearest hospital.

Frequently Asked Questions

The time it takes for Pentasa to work can vary by individual, but it is important to continue using it as prescribed.

There are no specific instructions regarding food interactions with Pentasa.

No, Pentasa is not considered addictive.

Do not stop taking Pentasa suddenly without consulting your doctor, as it may worsen your condition.